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[114] The FDA concluded in 2020 that kava is not generally recognized as safe (GRAS) for use in conventional foods due to evidence of toxicity, potential liver damage, possible carcinogenicity, drug interactions, and a lack of sufficient safety data

10.1111/j.1476-5381.1996.tb15472.x Br J Pharmacol

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Following infusion into a rat model with AF injury, there was a notable increase in the migration of AF cells to the injury site, which promoted anabolic upregulation (Wei et al., 2022)