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Subsequently, several studies also revealed other effects, such as intensifying cell motility, angiogenesis, immune response, cell differentiation, and anti-apoptosis (Garcia-Vilas and Medina, 2018)

6 Discussion In this review, we observed that the majority of oHSV clinical trials have employed various forms of viral modifications, such as deletions of genes 134.5, US11, US12, and UL39, or the expression of transgenes like GM-CSF and IL-12

Rudge P, Jaunmuktane Z, Adlard P, Bjurstrom N, Caine D, Lowe J, Norsworthy P, Hummerich H, Druyeh R, Wadsworth JDF, Brandner S, Hyare H, Mead S, Collinge J (2015) Iatrogenic CJD due to pituitary-derived growth hormone with genetically determined incubation times of up to 40 years

40 years

van den Anker JN, Allegaert K