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Daratumumab depletes CD38+ immune regulatory cells, promotes T-cell expansion, and skews T-cell repertoire in multiple myeloma

The metabolic pathways through which these molecules act to stimulate TAG hydrolysis and FA release have been studied extensively and reviewed in detail (6, 17, 18, 29, 63, 64, and references contained therein)

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It is important to keep in mind that, as with any supplement, the long-term effects of AOD 9604 are not fully understood, and more clinical research is needed