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Nanocarriers overcome these limitations by exploiting tumour-specific physiological and molecular features that enhance drug localisation and retention [136]

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doi: 10.1038/s41380-020-0645-4Google ScholarPubMed Pulvirenti, G., Valerio, C., Spadaro, F., D'Agata, V., Freni, V., Nardo, L., & Drago, F

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Overall, the administration of charged NPs need to be performed avoiding potential side effects related to the used NP concentration (Zhang et al., 2021a): nanocarriers with superficial cationic motifs exhibit a higher macrophage uptake and clearance by the mononuclear phagocyte system (MPS) compared to uncharged nanosystems, reducing the internalization in the targeted cells