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Muscle is a central endocrine mediator, particularly due to the production of myokines (i.e., myostatin, -aminoisobutyric acid, IL-15, irisin, meteorin-like and myonectin), which are critical mediators of the crosstalk between muscle and other tissues and organs to regulate metabolic homeostasis [166]

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In addition, no significant differences were observed in the rate of atypical endometrial hyperplasia between the MFP-treated groups and controls