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Exogenous risk factors such as an exposure to ultraviolet light, increase melanoma incidence, as well as skin damage with burns, frostbite and damage after radiotherapy, although the mechanism of the latter is not always clear

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Established low ranges are often too low, and researchers have found that normal-low B12 levels have been associated with neurological symptoms such as difficulty balancing, memory lapses, depression, mania, fatigue, and even psychosis

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For individuals with certain genetic conditions, these pathways are often dysfunctional, leading to extreme hunger and difficulty losing weight