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Cancer-induced heterogeneous immunosuppressive tumor microenvironments and their personalized modulation

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Research indicates that oxidative stress, which adversely affects the auditory system, is associated with noise-induced hearing loss, age-related hearing loss, and ototoxicity (Rybak et al

In a specific embodiment, Ab is an anti-FRa antibody which has one or more of the following properties: (i) it binds to the folate receptor receptor a (FRa) with a KD of 10OnM or less, preferably with a KD of 50 nM or less, as measured by surface plasmon resonance, such as Biacore assay