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For example, Lactiplantibacillus plantarum reduces the DNA-binding capacity of NF-B, thereby limiting the transcription of pro-inflammatory genes (258), whereas Lactobacillus brevis inhibits the phosphorylation of upstream kinases such as IRAK1 and AKT (259)

Inclusion criteria - Male and female individuals of at least 60 years of age at the time of the screening visit - Diagnosis of mild cognitive impairment (31) or dementia (32) due to AD according to NIA-AA 2011 criteria - Standardized mini-mental state examination score of at least 18 at the time of the screening visit - Living in a community setting without continuous nursing care - Can identify a reliable study partner with whom they have at least 3 weekly interactions to oversee study drug administration and participate in all clinic visits and some study procedures (including Cognitive Dementia Rating)

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We also sought comment on whether any overlap will depend upon whether the same or a different practitioner reports the services

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