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The benefit signal strengthens under oxidative load which means individuals with metabolic syndrome, cardiovascular disease, neurodegenerative risk, CKD, or those undergoing hemodialysis (where ET is depleted by 88%) represent the clearest candidates for supplementation trials

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These findings exhibited that EGb may facilitate improvements in sleep continuity and non-REM sleep among individuals with depression, potentially via the modulation of corticotropin-releasing hormone (CRH) activity, thereby presenting a promising adjunctive approach for the management of sleep disturbances associated with depression (69)

reported that SIRT3 was involved in the inhibitory effect of nicotinic alpha7 subtype of nicotinic acetylcholine receptors on platelet-derived growth factor-BB, an angiogenic factor, induced VSMC migration