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Acetate enters the citric acid cycle as acetyl-CoA

Yang F, Xiao Y, Ding JH, Jin X, Ma D, Li DQ, et al

Even with a healthy diet, deficiencies occur due to stress, poor gut absorption, or chronic illness

Mice undergoing in vivo reprogramming were found to become depleted in B 12 and show signs of methionine starvation while supplementing reprogramming mice and cells with B 12 increased reprogramming efficiency, indicating a cell-intrinsic effect