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In short-term trials, sedation or sleepiness was noted at low dosages and decreased in both intensity and frequency or progressively vanished during the titration of MTZ to higher levels (Bremner 1995

To initiate these responses, multiple signals must be integrated in secondary lymphoid organs such as the lymph nodes and spleen 5,9

Madsen, J

The important clue is that free iron is not as cytotoxic as hemin, as shown by incubations with iron (FeCl 2 and FeCl 3 ) that are not toxic in culture (preliminary data at [71]) and by knowing that the structure of hemin itself contributes to its toxicity [225]

This can occur for many reasons, and it does not always indicate a serious allergy