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Absorption quotient between the two assay conditions was calculated by the following equation: Absorption quotient (AQ) = (Papp, A-B with inhibitor - Papp, A-B without inhibitor)/Papp, A-B with inhibitor where Papp, A-B with inhibitor and Papp, A-B without inhibitor represent the apparent permeability of test compound from the apical to basal side of the cellular monolayer in the presence and absence of 10 P-gp inhibitor GF120918, respectively

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1 week, 4 weeks 1 x 10 mg vial 1 week: 7 evening draws

The lower availability of MOR in obese individuals may contribute to overeating as a way to compensate for reduced pleasure responses in this system

A peptide is simply a short chain of amino acids, too short to be called a protein