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2.1.1 TCM mechanisms in glucose regulation 2.1.1.1 Traditional Chinese medicines, classical formulas, and mechanistic insights into blood glucose regulation in T2DM A recent meta-analysis examined the most commonly reported TCMs used in diabetes care, historically referred to as dissipating thirst syndrome ( Supplementary Table 2

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The gain of function of SVCT2 in cortical precursors isolated from embryonic brains (E14) induces an increase in arborization and increases the expression of synaptic proteins such as Piccolo and PSD95 and the presence of dendritic spines with thin and mushroom shapes, as observed by SR-SIM and 3D reconstruction rendering analysis (Salazar et al., 2021)

However, its crucial to approach these results with appropriate scientific caution, recognizing they derive from controlled animal studies rather than definitive conclusions