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3,4 Presently, cellular-based approaches to regenerate cartilage focus on increasing the number of cells that can revitalize joints, either by recruiting progenitor cells or enhancing chondrocyte density through techniques such as microfracture or autologous chondrocyte implantation (Fig

[DOI] [Google Scholar] 108.De Almeida R., Fernando L., Fernando F., Mancini E., de Feo V

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In general, gene mutations with large biological effects (i.e., optic neuropathy) are rare whereas gene variants associated with smaller effects are common (12) (see below)