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4 Toxicity Drugs may have toxic effects due to various reasons

[6] Exceptions exist when elimination is extremely rapid: for very short-acting agents, the phase can meaningfully shorten effect duration even after a single dose (e.g., triazolam, midazolam)

We refer readers to the FY 2013 IPPS/LTCH PPS proposed and final rules for additional background and a detailed description of this methodology (77 FR 28145 through 28146 and 77 FR 53700 through 53701, respectively)

Most patients require 610 sessions spaced 12 weeks apart , followed by periodic maintenance sessions to sustain the effects