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This technology involves using a high-power laser to induce local PUFA acyl chains in cell or tissue samples, generating lipid peroxidation, and demonstrating the sensitivity of cells or tissues to ferroptosis inducers on-site (257)

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The pharmacology in animal studies and early human studies supported this design: AOD-9604 stimulates lipolysis and inhibits lipogenesis through activation of beta-3 adrenergic receptors in adipose tissue, without producing the IGF-1 elevation or insulin resistance signal that exogenous GH produces

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