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'Leaving' groups During its reaction with DNA the dichloro groups of cisplatin are displaced or substituted but the two ammine groups remain intact, leading to a convention to refer to the groups within platinum cancer drugs that are displaced as 'leaving groups' (and those that remain as stable or carrier ligands)

Although structural data are scarce, early research from DDT-metabolizing GST (agGSTd1-6) in mosquito Anopheles gambiae reported a fold similar to other insect d class GSTs (Chen et al., 2003), this being consistent with 57.77% of sequence identity between GST8 and agGSTd1-6

In addition, in recent years, it has been proposed that HSP response may be necessary for the body to acquire heat acclimation (HA) [32, 33]

The same recommendation applies for dapsone, a sulfone, which also does not need to be withheld

3.4 Food-medicine homologous herbs for modulation of other targets In the pathogenesis of DKD, inflammation, oxidative stress, and fibrosis represent the most critical pathological mechanisms