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Leo Nollet Handbook of Analysis of Active Compounds in Functional Foods , pp.73-74

Lack of this vitamin may also contribute to weakened immunity and recurrent infections, damage of the myelin sheaths of the nerve cells, birth defects, age-related hearing loss, or increased homocysteine levels and higher risk of cardiovascular problems

Here's what sits alongside your point: the math explains why things are the way they are, but most people hearing "no FDA approval" instantly think "not safe." The evidence exists

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Through these actions, metformin has been shown to exhibit several mechanisms