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10.1056/NEJMoa1903212 90 WagenerF

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All experiments were approved and performed in accordance with Swedish National Board of Laboratory Animals and the European Community Council Directive (86/609/EEC) under the permits N275-15 and N244-13

In particular, hypoxia imaging has been associated with radiotherapy resistance, while metabolic and acidosis-related imaging signals have been linked to tumour grade, proliferative activity, and early treatment response dynamics (198, 199)