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These findings might explain what we observed in this study, as the glucose metabolism increases, and as the Akkermansia is able to repair the intestinal wall, we observed a decreased level of inflammatory markers within the CNS, possibly due to decreased leaked from the gut 24,52,54,56

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In addition, we found that NAC treatment prevented THC-induced increases in the polyamine spermidine, which is known to regulate glutamatergic signaling by potentiating NMDA-receptor sensitivity to glycine [105]