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198 Moreover, ERK1/2 enhancement of claudin-2 expression is likely mediated by its downstream transcription factor AP-1, which could act as a transcriptional enhancer of claudin-2

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By enabling more predictive and mechanistic investigations, they hold significant promise for advancing the preclinical development of Epitalon as a multifunctional therapeutic candidate for the management of diabetes and its systemic complications

After removal of the hexanes phase, the pH of the aqueous phase was adjusted to 9.0 with concentrated NH 4 OH solution

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