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It has been demonstrated that polyphenols enhance mitochondrial function and defend them against oxidative damage

77,78 Pentoxifylline has been shown to decrease malondialdehyde concentration, increase the GSH:GSSG ratio, and enhance the expression of Nrf2, a key regulator of cellular oxidative stress, further validating its antioxidant properties

110 CR has been shown to prolong life and reduce age-related diseases, including cancer, in experimental models

Methods Constructs All amino acids are numbered according to the standard H77 polyprotein numbering (GenBank AF009606 104 )

After four washes with ELISA washing buffer, a 1:20,000 dilution of goat anti-human IgG-HRP (Jackson ImmunoResearch Cat