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The approach is so far limited by the fact that it has been performed successfully only in postoperative patients but not in patients with chronic diseases

doi:10.2174/1574884711308020006 91

Safety and tolerability of antagonist anti-human CD40 Mab ch5D12 in patients with moderate to severe Crohns disease

The primary source of free heme is hemoglobin derived from senescent red blood cells, and heme metabolism takes place in all mammalian cells (Figure 1)