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B vitamins, including B1, B2, B6, niacin, pantothenic acid, biotin, folic acid, and B12, play a crucial role in energy metabolism

Received 2021-10-17

As other Rho GTPases [48,49], Sept2 is crucially involved in modeling neurite outgrowth during neuronal differentiation and a tight regulation of its expression is necessary [50]

We demonstrate that the biosensors remain functional in motor neurons derived from these iPSCs and reflect the differences in the stationary redox state of the neurons with different genotypes

In addition, co-cultured astrocytes derived from ALS patients with human motor neurons led to high neuronal loss