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The number of axons was significantly decreased (especially in distal area) in comparison to other treatments (Fig

These changes were accompanied by strong metabolic differences in the faeces, caecal content, liver and gut tissues between TCDF-treated and control AhR +/+ mice, whereas TCDF had no effect on the metabolic profiles of AhR / mice

A phase II RCT showed that the ALT level and hepatic lipid accumulation of NAFLD patients were both decreased after 12 weeks of treatment with EDP-305, but the incidence of side effects, including pruritus and nausea, was also higher [207]

ZebIAhmadiNNasirKKadakiaJLarijaniVNFloresFet al

Extensive research on engineered nanomaterials has led to the design of numerous nano-based formulations, i.e., nanomedicines, for theranostic applications with one of the significant benefits lying in the ability to formulate a drug without using dose-limiting toxic excipients present in many current marketed formulations, often enhancing tolerability and containing more active molecules to be administered to patients [655,656]