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Sulfation The first step is the bioactivation of inorganic sulfate by enzyme called ATP sulforylase to give the coenzyme 3'-phosphoadosine-5-phosphosulfate (PAPS) Sulfation The second step here is the transfer of sulfate group from the coenzyme PABS to the acceptor drug by nucleophilic attack: As in all conjugation reactions: The endogenous polar group must be activated and converted into electrophilic derivative

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Confocal microscopy and image processing Confocal images were acquired using a Leica TCS SP8 confocal microscope

Tubocurarine is the main active ingredient in the South American arrow poison - curare

Correlation between mitochondrial DNA 4977bp deletion and presbycusis: A system review and meta-analysis