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However, its clinical utility is limited by safety concerns linked to prolonged benzodiazepine exposurespanning cognitive effects, falls and fractures, physiologic dependence, pneumonia, and respiratory complicationswith particularly heightened vulnerability in older adults and those with sleep-disordered breathing, and with long-term use associated with increased all-cause mortality 27,28,29,30,31

The r coefficients were generally low, except for Zn and Pb, where strong negative correlations were observed