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A pre-existing and inducible high expression of CD38 (as in mPCs) is thought to be the main hindrance to the therapeutic potential of the antiPD-1/PD-L1 blockade (Figure 3)

If thinning is diffuse rather than focal, systemic subcutaneous injection may outperform scalp-specific delivery

This contrasts sharply with full-length human growth hormone, which can impair glucose tolerance and insulin sensitivity, potentially precipitating or worsening diabetes