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In the first reciprocal network, the KFGs were primarily enriched in pathways such as regulatory actin cytoskeleton, NF-kappa B signaling, Toll-like receptor signaling, and MAPK signaling (Figure 3C

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Guan R, Wang J, Li Z, Ding M, Li D, Xu G, Wang T, Chen Y, Yang Q, Long Z, Cai Z, Zhang C, Liang X, Dong L, Zhao L, Zhang H, Sun D, Lu W (2018) Sodium tanshinone IIA sulfonate decreases cigarette smoke-induced inflammation and oxidative stress via blocking the activation of MAPK/HIF-1alpha signaling pathway