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Research has shown increased phosphorylation of extracellular signal-regulated kinases (ERK) 1 and 2, along with their downstream targets, including c-Fos, c-Jun, and Egr-1, which are molecules involved in cell growth, migration, and angiogenesis

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Mitochondrial dysfunction has been recognized as an early pathogenic event for ASD [354] and AD [355], which significantly impairs brain function, as we discuss above

In addition, with the growing insights into the production and utilization of one-carbon units in cancer cells, multiple therapeutic strategies have been proposed, including nutrient therapy and targeting enzymes in one-carbon metabolism pathways

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