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10.1371/journal.ppat.1004679 348 VanhaesebroeckB.StephensL.HawkinsP

Although studies with cereblon-based PROTACs are still scarce, it is expected that long-term clinical use of this type of degrader could lead to the emergence of mutations that prevent PROTAC from binding to cereblon, thus preventing poly-ubiquitination of the target protein

DOP are among the most common secondary OPs [5], and are closely associated with diabetes

Alterations in neurotransmitter levels in exposed animals were consistent with neurobehavioral effects in animals (eg, behavioral sensitization, spontaneous locomotor activity, sensorimotor gating, and auditory processing) and audiological effects identified in both humans and animals

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