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Studies in mice showed that administration of IL-10 reduced serum Hcy levels [92], suggesting a negative impact of IL-10 on Hcy (Figure 1)

HIFs are normally hydroxylated by PHDs and degraded, while under hypoxia, PHDs are suppressed, allowing HIF- to accumulate and transactivate multiple target genes, including erythropoiesis, and genes participate in angiogenesis, iron metabolism, glycolysis, glucose transport, cell proliferation, survival, and so on

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