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In this context, it is tempting to speculate that, in the chronic absence of PrP-mediated uptake, Cu still finds alternative pathways to enter Atp7B-deficient cells

Question of Bioavailability: The issue of bioavailability is another concern

Discovered in 1973 by biochemist Loren Pickart in human blood plasma, this copper-tripeptide has been the subject of over five decades of research that has progressively revealed the breadth of its biological functions

TREM2 (Triggering Receptor Expressed on Myeloid Cells 2) is a transmembrane receptor that is activated by a variety of ligands including lipids (Cannon et al., 2011