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Overexpression of wild-type (WT) ATP13A2, but not KRS pathogenic ATP13A2 mutants, protects mammalian cell lines and primary rat neuronal cultures from Mn 2+ -induced cell death by reducing intracellular Mn concentrations and cytochrome c release, suggesting a role of ATP13A2 in Mn detoxification and homeostasis (Tan et al., 2011)

NMD occurs worldwide in areas where the soil (and therefore the derived grains and forage) is deficient in selenium, and storage conditions do not preserve vitamin E in forages

Zhang Y, Li J, Zhang YM, Zhang XM, Tao J

LPS has long been recognized as a major mediator of bone loss in chronic infection by Gram-negative bacteria (Mormann et al., 2008)

However, current in vivo and in vitro models provided limited information about HDV infection and replication, which has impeded the development of effective therapies