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7, we speculated 4 pathway groups, which potentially influence on fatigue development, according to the results of Enrichment analysis, i.e., fatigue-related factors corrected by E-HD (Pathway A), as factors possibly affected by E-HD (Pathway B), or as events common to fatigue pathologies not influenced by E-HD (Pathway C), and as factors not affected by E-HD at all (Pathway D)

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Signatures of genes that 1) change in expression with regional emphysema severity in this dataset, 2) change in expression with lung function measures in other datasets [6, 7, 9, 10], or 3) change in expression with TGF treatment in other datasets [1923] were each used as separate queries into the CMap data