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Section 1886(d)(4)(C)(i) of the Act states that the Secretary shall adjust the weighting factors at least annually to reflect changes in treatment patterns, technology, and other factors which may change the relative use of hospital resources

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At physiological pH, cisplatin and monohydroxymonochloro cis -diamine platinum (II) are the predominant species and are present in nearly equal concentrations (FDA, 1978)

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