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Thereby, glutamine metabolism is essential for acid-base buffering [33] and also plays an important role in the biosynthesis of nucleotides, detoxification of ammonia, glutathione synthesis, and maintenance of nitrogen transfer between organs [5, 12, 34]

2 Methionine metabolism Methionine and its metabolites, not only participate in protein synthesis but also have functional roles

Keratinocytes act as a source of reactive oxygen species by transferring hydrogen peroxide to melanocytes