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153 Previous studies found that erastin was able to increase the sensitivity of various cancer cell lines to chemotherapy drugs, including doxorubicin, actinomycin D, cisplatin, temozolomide, and cytarabine, 154,155,156,157 providing new motivation for exploring the feasibility of combination therapies

Another study by Wan et al., conducted on healthy volunteers, revealed that AUC (0168 h) and AUC (0-) values of gefitinib were higher by 33% and 37%, respectively, in individuals with CA + AA genotypes than in patients with the CC genotype ( p G) of FOXO3 and found a significant association with hepatotoxicity, where the AA carriers had a higher tendency to develop hepatotoxicity than those with GG genotype ( p = 0.018) [96]

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