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Concurrently, SFN has been shown to improve anxiety and depression symptoms in mice by activating the Nrf2/ heme oxygenase-1 (HO-1) signaling pathway (Ferreira-Chamorro et al., 2018) and inhibiting the hypothalamicpituitaryadrenal (HPA) axis and stress response (Wu et al., 2016)

The present study supports these findings, as we show that an increased kynurenine/tryptophan (Kyn/Trp) ratio, a well-established marker of inflammation [63, 78, 79], correlates with manifest disease

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(59) investigated the effect of anxiety and depression symptoms on oxidative stress in AA patients

Meta-analyses published between 2022 and 2024 consistently report an 1824% elevation in lung cancer incidence among smokers receiving -carotene supplements, a finding corroborated by large-scale trials such as ATBC and CARET (246)