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Conversely, hypoxia and glucose deprivation in the brain promotes HDAC9 expression in endothelial cells, which has been associated to decreased expression of ZO-1, claudin-5, and occludin (Shi et al., 2016)

403 Given that vascular calcification is a cornerstone in preventing arterial stiffness, promising data suggest that the inhibition of tissue nonspecific alkaline phosphatase (TNAP) decreases cardiovascular calcification

3,13,14 Because these conditions may cause symptoms that overlap with those of anxiety, accurate diagnosis and appropriate treatment can be challenging

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