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For instance, the v6 splice variant of the hyaluronan receptor CD44 links c-MET signaling to the actin cytoskeleton via GRB2 and the ezrin, radixin and moesin (ERM) family of proteins in order to recruit SOS, which then amplifies RAS-ERK signaling [Orian-Rousseau et al

2.5 Immune microenvironment With the continuous study of tumor immunity, some researchers have proposed several immune subtypes of tumors based on the histological characteristics of tumors ( Figure 2 )