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Ferroptosis suppressor protein 1 (FSP1) is a key regulator of ferroptosis, acting independently of the GPX4 pathway (66)

Cellular redox signaling, influenced by fluctuations in ROS, RNS, and antioxidant systems, governs vital functions like cell growth, programmed death, and immune responses [112]

Methods: VIR-2218-1001 is a Phase 1/2 single and multiple ascending dose study at multiple sites in Asia-Pacific (APAC) region excluding mainland China

Results: Median age of the 1,267 with available HCV RNA data was 30 years, 4% were women, and 12% were HIV co-infected

10.1158/1078-0432.CCR-14-2469 106 KlonouA.KorkolopoulouP.GargalionisA