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Jouhourian says

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Funding Statement This work was funded by the University of Zagreb, Zagreb, Croatia (Grant BM 099)

Improved GH/IGF-1 does support tissue repair and recovery, but it's a broad systemic effect

Phosphorylation of IRF3 by TBK1 dimerizes and translocates IRF3 to the nucleus, inducing the expression of the type I interferon (IFN) gene, interferon-stimulated genes (ISGs), and several other inflammatory mediators, pro-apoptotic genes, and chemokines, which in turn are involved in various pathophysiological processes (141, 145, 146) ( Figure 2 )