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10.7554/eLife.34408 34 HiranoT.SuzukiN.IkenakaY.HoshiN.TabuchiY

Gently pull down the lower lid to form a pouch (Figure 2)

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Pomegranate-derived compounds have been shown to modulate a wide range of molecular targets, including transcription factors, pro- and anti-apoptotic proteins, cell cycle regulators, protein kinases, cell adhesion molecules, pro-inflammatory mediators, and growth factors across multiple cancer types, such as skin, breast, prostate, colon, and lung cancers (366, 367)