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Moreover, exposing mice to a low dose which reflects a typical American diet (0.01 mg/kg/day), caused gut microbiota alterations across two generations-consistent with earlier findings, Akkermansia muciniphila was depleted, while ParaBacteroides distasonis and Christensenellaceae were elevated in the second generation (Barnett et al., 2024)

For all these reasons, COPD remains a major worldwide health problem and global burden of disease studies have estimated COPD as the third leading cause of death worldwide [4]

A notable fact highlighted in scientific literature: its plasma concentration declines with age

For decades, the predominant model in anticancer drug development has been the one target: one drug approach using small molecules or biologics [2]

Cell Tissue Res (2019) 377:1615