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Dual signaling potential is common among Gs-coupled receptors and dependent on receptor density

Aloe vera at a lower concentration of 2.5% or 10% has been shown to improve the proliferation rates of human dermal fibroblasts, and MSCs, whereas anthraquinone derivatives found in aloe vera extracts induce apoptosis in human hepatocellular carcinoma (HepG2) (12.5 mg/mL) by mediating mitochondrial activity and P53 pathway (Farid et al., 2022)

(2018) 79:e12838

Lieberman MW, Wiseman AL, Shi ZZ, Carter BZ, Barrios R, Ou CN, Chevez-Barrios P, Wang Y, Habib GM, Goodman JC, Huang SL, Lebovitz RM, Matzuk MM

3) using the scikit-learn 68 python package