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Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1)

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IFN- can also repress the expression of the NAD + -dependent deacetylase SIRT-1 (Li et al., 2012) which is a critical coordinator of cellular metabolism acting primarily by deacetylation

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This mitochondrial dysfunction was accompanied by abnormal morphology of the brain mitochondria, and reduced synaptic density [382]

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