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Antioxidants and cancer therapy: furthering the debate

10.1016/j.phrs.2024.107413 141 WangQ.ShenW.ShaoW.HuH

showed that curcumin effectively counteracts doxorubicin (DOX)-induced neurotoxicity by suppressing autophagy while reducing oxidative and endoplasmic reticulum stress, with these protective effects mediated through activation of the Keap1-Nrf2-ARE signaling pathway

Consistently, in relapsed AML/MDS after allo-HCT, high frequencies of CTLA-4/PD-1 and multi-ICMco-expressing T cells and blasts are detectable in uncultured blood and associate with impaired antileukemic activity and poor response to salvage therapy (54)