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Detailed mechanism [edit] Two aspartate amino acid residues (below left) are interacting with two adjacent water molecules (w6 and w8) in the Mn 2+ isocitrate porcine IDH complex to deprotonate the alcohol off the alpha-carbon atom

Ann Bot 116:487496 de Pinto MC, Locato V, Paradiso A, De Gara L (2015b) Role of redox homeostasis in thermo-tolerance under a climate change scenario

Under normoxic conditions, HIF1 hydroxylation and degradation depend on the catalytic effect of prolyl-4-hydroxylase 2 (PHD2) and the downregulation of PHD2 activity is positively associated with pulmonary vascular remodeling and PAH (88,89)