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Materials 14 , 2611 (2021)

All experiments were approved by the Ethics Committee of the Plastic Surgery Hospital (Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

Here, we demonstrate that dihexa binds with high affinity to hepatocyte growth factor (HGF) and both dihexa and its parent compound Norleucine 1-AngIV (Nle1- AngIV) induce c-Met phosphorylation in the presence of subthreshold concentrations of HGF and augment HGF- dependent cell scattering

This regulation was shown to occur under the direct transcriptional control of GA-binding protein alpha (GABPA)a critical Ets-family transcription factor that acts as a master regulator of mitochondrial biogenesis by controlling the expression of nuclear-encoded mitochondrial proteins, and whose direct binding to the PHB2 promoter makes it a key upstream determinant of the cells capacity for mitophagy (60)

A clinical study involving 147 patients with osteoporotic vertebral compression fractures (OVCF) found that the unilateral group had significantly shorter operation times (41.60 5.64 min vs